Inhibition of gold thioglucose-induced hypothalamic obesity by glucose analogues.

LIKUSKI, HENRY J., ALBERT F. DEBONS, AND ROGER J. CLOUTIER. Inhibition of go Id thioghcose-induced hypothalamic obesity by glucose analogues. Am. J. Physiol. 2 12(3) 669-676. 1967.--Female CBA mice were used to determine the effect of the glucose inhibitors, 2-deoxy-n-glucose and 2-amino-2-deoxy-oglucose on gold thioglucose-induced hypothalamic obesity. A marked inhibition in the incidence of obesity resulted when gold thioglucose was administered to mice receiving 2-deoxyn-glucose (I g/kg body wt) or 2-amino-2-deoxy-n-glucose (3 g/kg body wt). Gold d eposits at the site of the hypothalamic lesion were readily observed, after neutron activation using autoradiographic techniques, in all gold thioglucose-treated animals. These deposits were more extensive in obese than in nonobese mice. The results indicated that 2-deoxy-D-glucose and its amino analogue interact with cells in the “satiety center” to inhibit gold thioglucose-induced hypothalamic damage and obesity. In a separate study, a pronounced hyperphagic response was noted while 2-deoxy-n-glucose was administered to control (untreated) animals. This finding tends to further support the contention that a-deoxy-n-glucose interacts with cells in the satiety center.